Cirrhotic Cardiomyopathy

Potential mechanisms involved in the impaired contractile function of the cardiomyocyte in cirrhotic cardiomyopathy: Down-regulation of β-adrenergic receptors with decreased content of G-protein (Gαi: inhibitory G-protein; Gαs: stimulatory G-protein); up-regulation of cannabinoid 1-receptor stimulation; increased..

Potential mechanisms involved in the impaired contractile function of the cardiomyocyte in cirrhotic cardiomyopathy: Down-regulation...

Liver Cirrhosis

Vascular and architectural alterations in cirrhosis Mesenteric blood flows via the portal vein and the hepatic artery that extend branches into terminal portal tracts. A, normal liver: Terminal portal tract blood runs through the hepatic..

Vascular and architectural alterations in cirrhosis Mesenteric blood flows via the portal vein and the...

Couinaud’s Segmental Anatomy of the Liver and Proposed Classification of Pediatric Liver Tumors

PRETEXT is distinct from Couinaud 8-segment (I–VIII) anatomic division of the liver. PRETEXT defines 4 ‘Sections’. Boundaries of each section defined by the right and middle hepatic veins, and umbilical fissure. FROM: Modern Pathology (2014)..

PRETEXT is distinct from Couinaud 8-segment (I–VIII) anatomic division of the liver. PRETEXT defines 4...

Replication of Hepatitis C Virus

Exciting progress has recently been made in understanding the replication of hepatitis C virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. The development of complete cell-culture systems should now enable..

Exciting progress has recently been made in understanding the replication of hepatitis C virus, a...

Hypothesized Steatosis–Hepatocellular Carcinoma Pathway

In the absence of common hepatic insults, such as excess alcohol, accumulation of fat in the liver (nonalcoholic fatty liver disease (NAFLD)) is associated with chronic inflammation, known as nonalcoholic steatohepatitis (NASH). In some subpopulations,..

In the absence of common hepatic insults, such as excess alcohol, accumulation of fat in...

Pathogen-Specific Adaptive Immunity

a | Scavenger sinusoidal cell populations, such as Kupffer cells, phagocytose circulating bacteria and crosstalk with natural killer T (NKT) cells to generate strong intravascular pathogen-specific immune responses. Inhibiting the access of pathogens to hepatocytes..

a | Scavenger sinusoidal cell populations, such as Kupffer cells, phagocytose circulating bacteria and crosstalk...