This month’s key articles selected by Ryan Chadha, Prashant Bhangui, Uzung Yoon, David Victor, Felipe Alconchel, and Tamer Shaker.

Annals of Surgery

Blood Salvage and Autotransfusion Does Not Increase the Risk of Tumor Recurrence After Liver Transplantation for Advanced Hepatocellular Carcinoma

Previous studies have consistently demonstrated the safety of autotransfusion of salvaged and leukoreduced blood during liver transplantation for HCC. However, the effects of this technique remained unknown for advanced HCC. Read more.

Transplant International

Clinical Impact of Mild to Moderate Pulmonary Hypertension in Living-Donor Liver Transplantation

Severe pulmonary hypertension (PHT) is a contraindication to liver transplantation (LT); however, the prognostic implication of mild to moderate PHT in living-donor LT (LDLT) is unknown. Read more.

World Journal of Gastroenterology

Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation

The impact of perioperative blood transfusion on short- and long-term outcomes in pediatric living donor liver transplantation (PLDLT) must still be ascertained, mainly among young children. Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation. Read more.

Transplantation

Safety and Reactogenicity of 2 Doses of SARS-CoV-2 Vaccination in Solid Organ Transplant Recipients

We studied the safety and reactogenicity SARS-CoV-2 mRNA vaccines in transplant recipients because immunosuppressed patients were excluded from vaccine trials. Read more.

Clinical Transplantation

An evaluation of the safety and preliminary efficacy of peri- and post- operative treprostinil in preventing ischemia and reperfusion injury in adult orthotopic liver transplant recipients

Orthotopic liver transplantation (OLT) is the only treatment option for various end-stage liver diseases. Ischemia and reperfusion (I/R) injury is one of the unavoidable complications/conditions in OLT. Read more.

Liver Transplantation

Differences between infectious disease events in first liver transplant versus re-transplantation in the Swiss Transplant Cohort Study

Re-transplantation after graft failure is increasingly performed, but inferior graft survival, patient survival and quality of life has been reported. The role of infectious disease (ID) events in this less favorable outcome is unknown. Read more.

Transplantation

Coagulation Factors Accumulate During Normothermic Liver Machine Perfusion Regardless of Donor Type and Severity of Ischemic Injury

Coagulation factors may inform on liver function during normothermic machine perfusion (NMP). We investigated whether graft ischemic injury impairs the accumulation of (anti)coagulation factors during NMP of porcine and human livers. Read more.

Clinical Transplantation

Donor-recipient Body Size Mismatch Has No Impact on Outcomes After Deceased Donor Whole Liver Transplantation: Role of Donor Liver Size Measurement

The role of donor-recipient body size mismatch (DRSM) on outcomes after whole liver transplantation (LT) is not clearly defined. At our center, in presence of considerable DRSM, objective assessment of the donor liver by a radiology or intraoperative evaluation by procuring surgeon was incorporated. Read more.

New England Journal of Medicine

Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial

Transplantation of livers obtained from donors after circulatory death is associated with an increased risk of nonanastomotic biliary strictures. Hypothermic oxygenated machine perfusion of livers may reduce the incidence of biliary complications, but data from prospective, controlled studies are limited. Read more.