ILTS Insights: The Power of AI to Optimize Liver Transplant Allocation and Outcomes

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November 4, 2021

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Overview

Agenda:

  • Introduction – Mamatha Bhat
  • How to Apply AI tools in my liver transplant research: the Computer Scientist’s perspective – Bo Wang
  • Optimizing Donor-Recipient Matching using Machine Learning Algorithms – Javier Briceno
  • Q&A moderated by Mamatha Bhat and Eliano Bonaccorsi-Riani
Speaker Details

Bo Wang

Speaker

Dr. Bo Wang is an Assistant Professor in the departments of Laboratory Medicine & Pathobiology and Computer Science at the University of Toronto. He is also the inaugural Temerty Professor in AI Research and Education in Medicine. Dr. Wang also leads the AI team in Peter Munk Cardiac Centre at the University Health Network. He is also a Faculty Member at the Vector Institute and a CIFAR AI chair. Dr. Bo Wang obtained his PhD from the Department of Computer Science at Stanford University in 2017. His PhD work covers statistical methods for solving problems in computational biology with an emphasis on integrative cancer analysis and single-cell analysis and has published multiple first-authored papers in world-renowned journals such as Nature Methods and Nature Communications.

Javier Briceño

Speaker

Javier Briceño, M.D, PhD is Chief of the Department of General and Digestive Surgery and Head of liver and pancreas transplant programs at the Reina Sofía University Hospital, Córdoba, Spain. He is currently the Coordinator of the abdominal organ transplant Section of the Spanish Association of Surgeons (AEC) and former scientific director of the Spanish Liver Transplant Society (SETH). He is the Research Coordinator within the solid organ transplant area of ​​the Maimonides Biomedical Research Institute of Córdoba (IMIBIC). He is also a Member of the Royal Academy of Medicine of Seville, Spain.

Mamatha Bhat

Moderator

Dr. Mamatha Bhat is a staff Hepatologist and clinician-scientist at UHN’s Multi Organ Transplant Program and Assistant Professor at the University of Toronto’s Division of Gastroenterology & Hepatology. The goal of Dr. Bhat’s research program is to enable a precision medicine approach to long-term complications after liver transplantation through a better understanding of their mechanistic basis. She has been specifically examining non-alcoholic steatohepatitis and hepatocellular carcinoma in the context of liver transplantation. Her research program employs a bench-to-bedside paradigm that connects clinical outcomes with basic research using bioinformatic analysis of ‘omic datasets (e.g., transcriptomic, miRNA, methylation, intestinal microbiome) and machine learning tools.

Eliano Bonaccorsi-Riani

Moderator

Dr Eliano Bonaccorsi-Riani is a Liver Transplant Surgeon at the Liver Transplant Unit at Cliniques Universitaires Saint-Luc (CUSL), Université Catholique de Louvain (UCL) in Brussels, Belgium. He has an active role in the Living Donor Liver Transplant Program of this institution. His research interest focuses on the tolerance and rejection biomarkers in liver transplantation. Dr. Bonaccorsi-Riani is also a senior investigator at the Pôle de Chirurgie Expérimentale et Transplantation at the Institute de Recherche Clinique (UCL) where he develops and conducts experimental research projects using the rodent liver transplant model to investigate the mechanisms underlying the post liver transplantation tolerance establishment.

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